[xi] R M Yousuf,
MD, A R M Fauzi, MRCP, S H How, M. Med, A Shah, MSc. Metabolic Changes During Ramadan Fasting In Normal People And Diabetic Patients. International Medical Journal Vol 2 No 2 December 2003
1.0 PUASA WITH PHYSIOLOGICAL IMPAIRMENTS
The following
are allowed to break the puasa because of physiological weaknesses: the elderly, al shaikh[i], the pregnant woman, al hublah[ii] if fasting is a risk to the health of the fetus and not the mother, the breast-feeding woman or nursing woman, al murdhi'[iii] if puasa is a risk to the health of the baby; and breast-feeding woman or nursing woman, al murdhi[iv] if puasa is a risk to the health of the mother, and the menstruating woman, al
haidhah[v].
The very sick
with chronic disease and the elderly do not undertake puasa but feed the poor instead[vi].. Those with curable diseases fast the missed days when they recover. The
puasa of a sick person is valid but is makruh.
Diabetes mellitus
being a physiological decompensation is covered under the general legal exemptions from puasa.
However there are differences in the rulings depending on the type of disease. The rulings about puasa differ between insulin dependent and non-insulin dependent diabetics.
Insulin-dependent
diabetics have to reduce their insulin dose because of reduced food intake during the day. In some cases this is not possible
and they have to be exempted from fasting altogether especially if their diabetic control is brittle.
Non-insulin diabetics
can undertake puasa under medical supervision. This will generally require changing
times of medication, close monitoring of blood sugar levels, and being alert to any hyperglycemic or hypoglycemic crises.
Pregnant diabetics
are exempted from fasting because diabetic control is more difficult in pregnant women making fasting doubly hazardous for
both the mother and the fetus.
2.0 MEASURES TO PREVENT PHYSIOLOGICAL HARM:
The prophet (PBUH)
taught measures to ensure that puasa does not cause physiologic damage. Puasa continuously from day to day, wisaal,
was forbidden[vii]. Early iftaar was recommended[viii]. Delaying suhuur was recommended[ix].
3.0 MEDICAL GUIDELINES FOR PUASA:
The aim should
be maintaining normal body weight or actually reducing it if overweight. Over-eating at iftaar and suhuur should
be avoided. Over-eating will cause indigestion.
The diet should
contain sufficient fiber to prevent constipation. Fiber and slowly digested foods with a long stomach transit times are preferred.
Enough water should
be taken at night both for preventing dehydration and preventing constipation. Adequate fluid and salt intake prevents lethargy
in the afternoon caused by low blood pressure.
Hunger is a cause
of headache especially later in the day.
Intake of adequate
calcium, magnesium, and potassium will prevent muscle cramps.
Hot places should
be avoided. Attempts should be made to keep cool.
Inadequate sleep
is a cause of headaches.
In non-diabetics
hypoglycemia may be due to insulin overproduction on intake of refined sugar. In diabetics it may arise due to insulin injections
with inadequate dietary intake.
Peptic ulcers are aggravated by raised acid levels. Kidney stones may be due to low fluid intake. Joint
pains may be due to excess solutes.
5.4 MEDICATION IN PUASA
The general rule
is that any substance that enters the body through any of its openings, manfadh,
nullifies puasa. The openings are the two ends of the alimentary canal, the mouth
and the anus as well as the vagina.
All drugs that
are applied externally on the skin do not nullify puasa. Sub-cutaneous, intra-muscular, and intra-venous injections do not
nullify fasting. However nourishing injections nullify the purpose of puasa.
Drugs of whatever
form taken orally, per anus, or per vagina nullify puasa.
Venepuncture does
not nullify puasa.
Sub-lingual pills
are allowed.
The medication
schedule can be modified such that drugs are taken only during the night hours.
6.0 RECENT RESEARC ON PUASA AND DIABETES
6.1 Studies on
the effect of puasa on diabetic control have given many contradictory results. This is due to lack of careful control for
confounding factors and the general change in dietary habits that occurs in Ramadhan compared to other months of the year.
We will here quote only 2 of such studies.
6.2 Azwany et
al [x] studied the impact
of Ramadan fasting on glycemic control in type 2 diabetes patients. Forty-three
Muslim type 2 diabetic patients or oral medication, with no renal or liver disease participated in the study. A total of 52
patients had been recruited giving a drop-out rate of 17.3%. Fasting blood glucose (FBG) and serum fructosamine levels were
determined at four consecutive visits (at four weeks and one week before Ramadan, in the fourth week of Ramadan and four weeks
after Ramadan). They found no significantly change in mean FBG over time (Figure 1, p=0.12). There was however an increase
in fructosomine from the first to the fourth weeks (figure 2, p=0.001). The study showed poor diabetic control because the
subjects were more hyperglycaemic in Ramadhan. They concluded that the poor control reflected lack of knowledge about adjusting
diet and medication during Ramadhan.
6.3 Yousef et
al[xi] undertook a study to study the effects of Ramadhan on various physiological
parameters in normal and diabetic patients (NIDDM). The study group consisted of 53 diabetic patients (31 male and 22 female) and 56 (21 male 35 female) healthy volunteers as controls. The
subjects were evaluated 1-2 weeks before commencement of fasting (visit 1), at the 4th week of Ramadan fasting
(visit 2) and one month after the end of the Ramadan fast (visit 3). Results are shown in Tables 1 and 2. They found statistically significant weight reduction (P<.001) at the end of Ramadan fast in both groups which was not maintained
one month after Ramadhan. Fasting blood sugar and HBA1C showed significant reduction (P<.001) among diabetics but not in
control group. However serum cholesterol, triglyceride, and uric acid increased among healthy volunteers (control group) one
month after Ramadan; no such changes were seen among diabetic group.
FIGURE 1: MEAN FBG (MMOL/L) IN 43 SUBJECTS BY WEEK IN RELATION
TO RAMADAN
FIGURE 2: MEAN SERUM FRUCTOSAMINE LEVEL (mMOL/L) IN 43 SUBJECTS BY WEEK IN RELATION TO RAMADAN.
*Significant difference from 4th
week of Ramadan p<0.001
TABLE 1: LABORATORY
VALUES* TESTED AMONG DIABETIC PATIENTS AND CONTROLS BEFORE FASTING (VISIT 1) AND DURING RAMADAN (VISIT 2). Data is show
|
Diabetic patients (n=53) |
Controls (n=50) |
|
Visit 1 |
Visit 2 |
P value |
Visit 1 |
Visit 2 |
P value |
Weight(kg)
|
70.7±12.6
|
69.8±12.6 |
.012 |
60.6±13.7 |
58.6±12.4 |
.001 |
Fasting blood sugar (mmol/L) |
10.6±4.1 |
8.5± 3.4 |
.001 |
5.6± 0.70 |
5.4±0 .71 |
NS |
Cholesterol (mmol/L) |
5.7±1.08 |
5.9 ±0.9 |
NS |
5.4 ± 0.9 |
5.6 ± 0.9 |
NS |
Triglyceride(mmol/L) |
1.8± .93 |
1.7 ±0.9 |
NS |
0.8±0 .51 |
0.8 ± 0.6 |
NS |
Urea(mmol/L) |
4.2± 1.5 |
4.5±2.3 |
NS |
3.6± 1.07 |
3.8± 2.3 |
NS |
Creatinine(mmol/L) |
82.±26 |
86±28 |
NS |
76.2 ±2.4 |
76.04± 19 |
NS |
Uric acid (micromol/L) |
385±134 |
376±97 |
NS |
281.3± 85 |
290± 77 |
NS |
*all values are expressed
as mean ± standard deviation
NS: not statistically significant
TABLE 2: LABORATORY VALUES* TESTED AMONG
DIABETIC PATIENTS/ CONTROLS BEFORE FASTING (VISIT1) AND ONE MONTH AFTER FASTING (VISIT3):
|
diabetic patients
n=50 |
controls
n=48 |
|
|
Visit 1
|
Visit 3
|
P value |
Visit 1
|
Visit 3
|
P value |
Weight (Kg) |
70.8±12.6 |
70.7± 12.5 |
NS |
60.5±13.8 |
59.1±13 |
NS |
Fasting blood sugar (mmol/L) |
10.8±4.1 |
9.06±3.8 |
.002 |
5.5±0.6 |
4.9±0.7 |
NS |
HBA1C |
7.35±2.03 |
6.7±1.6 |
.001 |
4.84±0.6 |
4.86±0.5 |
NS |
Cholesterol(mmol/L) |
5.7±1. 09 |
5.7± 1.16 |
NS |
5.5± 1 |
5.8 ±1.16 |
.001 |
Triglyceride(mmol/L) |
1.7±0.4 |
1.8±1.3 |
NS |
0.78±0 .5 |
1. ±0.6 |
.001 |
Urea(mmol/L) |
4.1±1.4 |
5±2.5 |
NS |
3.5±1 |
4.3±1.3 |
NS |
Creatinine(mmol/L) |
79.4±23 |
81±26.3 |
NS |
75.5±17 |
90±22 |
NS |
Uric acid (micro mol/L) |
381±136 |
365±109 |
Ns |
278±84 |
320±95 |
0.01 |
*all values are expressed
as mean 7± standard deviation
NS: not statis
[x] N. Azwany , Aziz A Ismail, W.B.W. Mohammad, A.K.Al-Mahmood.: Effect Of Ramadan Fasting On Glycemic Status Of Type
2 Diabetic Patients In Northern Malaysia. International Medical Journal Vol 2 No 2 December
2003
[xi] R M Yousuf,
MD, A R M Fauzi, MRCP, S H How, M. Med, A Shah, MSc. Metabolic Changes During Ramadan Fasting In Normal People And Diabetic Patients. International Medical Journal Vol 2 No 2 December 2003